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Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists

โœ Scribed by Bolli, Martin H.; Marfurt, Judith; Grisostomi, Corinna; Boss, Christoph; Binkert, Christoph; Hess, Patrick; Treiber, Alexander; Thorin, Eric; Morrison, Keith; Buchmann, Stephan; Bur, Daniel; Ramuz, Henri; Clozel, Martine; Fischli, Walter; Weller, Thomas


Book ID
121865195
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
571 KB
Volume
47
Category
Article
ISSN
0022-2623

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Benzofuran-substituted urea derivatives
โœ Reema K. Thalji; Nambi Aiyar; Elizabeth A. Davenport; Joseph A. Erhardt; Lorena ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 249 KB

Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.