ChemInform Abstract: Synthesis and Characterization of 1,3-Dihydro-benzo[b][1,4]diazepin-2-one Derivatives. Part 4. In vivo Active Potent and Selective Non-competitive Metabotropic Glutamate Receptor 2/3 Antagonists.
β Scribed by Thomas J. Woltering; Juergen Wichmann; Erwin Goetschi; Frederic Knoflach; Theresa M. Ballard; Joerg Huwyler; Silvia Gatti
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 21 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of Novel Succinamide Derivatives Having a 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Skeleton as Potent and Selective M 2 Muscarinic Receptor Antagonists. Part 2. -Among the screened compounds derivative (IIIe) exhibits the highest affinity for M 2 muscarinic receptors and (III