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Novel and enantioselective syntheses of (R)- and (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid: a synthon for sitagliptin and its derivatives

✍ Scribed by Meryem Fistikci; Ozlem Gundogdu; Derya Aktas; Hasan Secen; M. Fethi Sahin; Ramazan Altundas; Yunus Kara


Book ID
113929307
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
218 KB
Volume
68
Category
Article
ISSN
0040-4020

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Synthesis and utilisation of chiral 3-hy
✍ Ganesh Pandey; Parthasarathi Das; Paidi Y. Reddy πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 106 KB

A novel strategy for the enantioselective synthesis of several a-hydroxy carboxylic acids by the nucleophilic alkylation of chiral 3-hydroxy-(YS, 8aS)-perhydropyrrolo [2,1-C] [1,4] oxazin -4 one is reported.