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Synthesis and utilisation of chiral 3-hydroxy perhydropyrrolo [2,1-c] [1,4] oxazin-4-one as a novel precursor for the enantioselective synthesis of α-hydroxy carboxylic acids

✍ Scribed by Ganesh Pandey; Parthasarathi Das; Paidi Y. Reddy

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 106 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01530-5

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✦ Synopsis

A novel strategy for the enantioselective synthesis of several a-hydroxy carboxylic acids by the nucleophilic alkylation of chiral 3-hydroxy-(YS, 8aS)-perhydropyrrolo [2,1-C] [1,4] oxazin -4 one is reported.

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