A new series of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones possessing MCH-1 receptor antagonism is presented. Suzuki coupling of boronic acids with key triflate 6 allowed rapid generation of a range of analogs. The SAR of the MCH-1 receptor was explored with a variety of aryl and heterocyclic moieties
Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases
✍ Scribed by T.K. Sasikumar; Li Qiang; Duane A. Burnett; William J. Greenlee; Brian E. Hawes; Timothy J. Kowalski; Kim O’Neill; Brian D. Spar; Blair Weig
- Book ID
- 108074111
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 132 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0960-894X
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