Central type Ca2+ channel modulators as targets for the novel treatment of psychiatric diseases
✍ Scribed by Yasuo Watanabe
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 77 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
In order to develop novel central acting drugs, the modulation of intracellular Ca 2 dynamics must be considered as an essential factor, since following excessive Ca 2 in¯ux to neuronal cells, abnormal intracellular Ca 2 concentrations induce several types of mental and neurological disorders. This paper introduces some voltage sensitive Ca 2 channel blockers (Ca antagonists) which may be useful in the treatment of neuro-psychiatric diseases, such as manic depressive insanity, schizophrenia, ischemia-induced neuronal death and/or amnesia. The pharmacological actions of Ca antagonists may be explained by these possible direct central actions due to permeation of the blood-brain barrier. Furthermore, the central pharmacological actions of Ca antagonists may be explained by these possible direct central actions due to permeation of the blood-brain barrier. Furthermore, the central pharmacological properties of newly synthesized GABA-peptides, which in¯uence cytosolic Ca 2 levels and bind to GABAA receptor, are also discussed as a novel class of psychiatric drugs. # 1998 John Wiley & Sons, Ltd.
KEY WORDS Ð Ca antagonists; neuropsychiatric diseases; novel neuronal Ca 2 modulators; newly synthesized GABA-peptides; voltage sensitive Ca 2 channels PROPERTIES OF NEURONAL Ca 2 CHANNEL SUBTYPES Recent studies have de®ned that CNS neurons greatly share VOC Ca 2 channel currents in the order of L-type 4 N-type 4 R-type 5 P-type, though the share ratio of each current component is dierent according to the brain region (Shibuya CCC