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Novel Alkoxyamine Linker to Load Ketones for Solid-Phase Synthesis: Application of the Synthesis of 1,4-Benzodiazepine-2-ones

✍ Scribed by Matsushita, Kimihito; Okamoto, Chieko; Yoshimoto, Mayumi; Harada, Kenichi; Kubo, Miwa; Fukuyama, Yoshiyasu; Hioki, Hideaki


Book ID
120089405
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
563 KB
Volume
12
Category
Article
ISSN
1520-4766

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A novel method for solid-phase synthesis
✍ Nicholas Drinnan; Michael L West; Max Broadhurst; Barrie Kellam; Istvan Toth πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 95 KB

The application of the N-1- (4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker for the solid-phase synthesis of oligosaccharides is described. The oligosaccharide products can be cleaved from the resin by hydrazine, ammonia or primary amines, but the linker is stable under the conditions of o