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A Novel Synthesis of 2,3-Disubstituted Benzopyran-4-ones and Application to the Solid Phase

โœ Scribed by Lalgudi S Harikrishnan; H.D.Hollis Showalter


Book ID
108379545
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
130 KB
Volume
56
Category
Article
ISSN
0040-4020

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Solid-phase synthesis of 1,3-disubstitut
โœ Shingo Makino; Eiji Nakanishi; Takashi Tsuji ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 88 KB

We have developed a solid-phase synthesis of diverse 1,3-disubstituted 2-thioxoquinazoline-4-ones. In this synthesis, the fluorine atom on support-bound 2-fluoro-5-nitrobenzoyl amides was substituted with various primary amines, followed by cyclization with thiocarbonyldiimidazole. Since 1-substitut