An Efficient Process for the Synthesis of trans-2,3-Disubstituted-2,3-dihydro-4H-1-benzopyran-4-ones (Chroman-4-ones)
β Scribed by Richard W. Draper; Bin Hu; Radha V. Iyer; Xun Li; Yuelie Lu; Mohammad Rahman; Eugene J. Vater
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 158 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Methyl 2-(4-hydroxybutyl)-4-oxo-4~-1-benzopyran-3-carboxylate 6 1s transformed mto the sproacetals 13 and 14 (ratio 5 1) vw treatment with mdomethane&otassmm carbonate, the process mvolvmg sequenaal mtramolecular conjugate addmon and enolate alkylafion The 2,3-epoxlde 7 derived from 6 undergoes spuw
A simple method for the preparation of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2dioxides is described. Treatment of N-sulfonyl ketimines 2 and 3 with different carbon nucleophiles afforded the corresponding of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides 1 i