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A novel method for solid-phase synthesis of oligosaccharides using the N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker

✍ Scribed by Nicholas Drinnan; Michael L West; Max Broadhurst; Barrie Kellam; Istvan Toth

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
95 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The application of the N-1- (4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) linker for the solid-phase synthesis of oligosaccharides is described. The oligosaccharide products can be cleaved from the resin by hydrazine, ammonia or primary amines, but the linker is stable under the conditions of oligosaccharide synthesis. The first sugar can be attached to the resin linker via a vinylogous amide bond, or by ether linkage using a p-aminobenzyl alcohol converter.

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