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Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists

✍ Scribed by Elfatih Elzein; Rao Kalla; Xiaofen Li; Thao Perry; Eric Parkhill; Venkata Palle; Vaibahv Varkhedkar; Art Gimbel; Dewan Zeng; David Lustig; Kwan Leung; Jeff Zablocki


Book ID
108073829
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
135 KB
Volume
16
Category
Article
ISSN
0960-894X

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Inside Cover: Tritium-Labeled N1-[3-(1H-
✍ Patrick Igel; David Schnell; Günther Bernhardt; Roland Seifert; Armin Buschauer; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

## Abstract The inside cover picture shows the human histamine H~2~ receptor and the H~2~ and H~3~/H~4~ receptor‐selective ligands identified. Bioisosteric replacement of the imidazole ring of the __N__^G^‐acyl‐imidazolylpropylguanidine with 2‐aminothiazole yielded potent and selective H~2~ recepto