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2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

✍ Scribed by Bernd Büttelmann; Alexander Alanine; Anne Bourson; Ramanjit Gill; Marie-Paule Heitz; Vincent Mutel; Emmanuel Pinard; Gerhard Trube; René Wyler


Book ID
108477412
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
163 KB
Volume
13
Category
Article
ISSN
0960-894X

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1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl
✍ Alexander Alanine; Anne Bourson; Bernd Büttelmann; Ramanjit Gill; Marie-Paule He 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 218 KB

Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B subtype selective NMDA receptor antagonist. The structure-activity relationships developed in this series resulted in the discovery of a novel