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Heteroaryl-Substituted 4-(1H-pyrazol-1-yl)-5,6-dihydro-1H-pyrrolo[2,3-d]pyrimidine Derivatives as Potent and Selective Corticotropin-Releasing Factor Receptor-1 Antagonists

✍ Scribed by Fabio Maria Sabbatini; Romano Di Fabio; Yves St-Denis; Anna-Maria Capelli; Emiliano Castiglioni; Stefania Contini; Daniele Donati; Elettra Fazzolari; Gabriella Gentile; Fabrizio Micheli; Francesca Pavone; Marilisa Rinaldi; Alessandra Pasquarello; Maria Grazia Zampori; Pina Di Felice; Paola Zarantonello; Roberto Arban; Benedetta Perini; Giovanni Vitulli; Roberto Benedetti; Beatrice Oliosi; Angela Worby


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
218 KB
Volume
3
Category
Article
ISSN
1860-7179

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✍ Roberto Arban; Roberto Benedetti; Giorgio Bonanomi; Anna-Maria Capelli; Emiliano 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

## Abstract Two new classes of potent and selective CRF~1~ receptor antagonists are presented. Exploration of general templates **3** and **4** through modifications of the top amine and bottom phenyl substituents led to optimization of the in vitro affinity and pharmacokinetic profiles. The typica