Novel 1,3-diene synthesis from alkyne and ethylene by ruthenium-catalyzed enyne metathesis

✍ Scribed by Atsushi Kinoshita; Norikazu Sakakibara; Miwako Mori

• Book ID: 104209397
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 795 KB
• Volume: 55
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(99)00297-5

✦ Synopsis

A novel 1,3-diene synthetic method from alkyne and ethylene was developed using ruthenium-catalyzed enyne metathesis. The reaction procedure is very simple: A CH2CI 2 solution of alkyne was stirred at room temperature under ethylene gas (1 atm.) in the presence of a catalytic amount of ruthenium benzylidene complex. The yield was good and the conversion yield was high. Dienes having functional groups such as a keto-carbonyl group, silyloxy group, ester, and ketal were synthesized from the corresponding alkynes and ethylene. In this reaction, the alkyne having a hetero atom at the propargylic position gave a good result and ether oxygen or amine nitrogen that coordinate strongly to the ruthenium catalyst prevents the reaction.