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Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome

✍ Scribed by Fabian Fernandez; Jonathan C. Trinidad; Martina Blank; Dong-Dong Feng; Alma L. Burlingame; Craig C. Garner


Book ID
111181529
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
521 KB
Volume
110
Category
Article
ISSN
0022-3042

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Ts65Dn mice are a genetic model for Down syndrome. Both individuals with Down syndrome and Ts65Dn mice have reduced cerebellar volumes and the cerebellum is involved in motor learning. ConΒ―icting results have been reported on the motor learning abilities of Ts65Dn mice, which may be related to proce

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Mouse genetic models can be used to dissect molecular mechanisms that result in human disease. This approach requires detection and demonstration of compelling parallels between phenotypes in mouse and human. Ts65Dn mice are at dosage imbalance for many of the same genes duplicated in trisomy 21 or