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Norcantharidin analogues — Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines

✍ Scribed by Deng, Liping; Shen, Li; Zhang, Jing; Yang, Bo; He, Qiaojun; Hu, Yongzhou

Book ID
111870236
Publisher
NRC Research Press
Year
2007
Tongue
French
Weight
137 KB
Volume
85
Category
Article
ISSN
0008-4042

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Diels-Alder addition of furans (furan, furfuryl alcohol, and 3-bromofuran) to maelic anhydride yields three distinct 5,6-dehydronorcantharidins. Hydrogenation of (4,10-dioxatricyclo[5.2.1.0]decane-3,5-dione) (4a), in dry ethanol affords the monoester (7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic aid