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Conformationally Restricted Analogues of 1N , 12N -Bisethylspermine: Synthesis and Growth Inhibitory Effects on Human Tumor Cell Lines

โœ Scribed by Reddy, Venodhar K.; Valasinas, Aldonia; Sarkar, Aparajita; Basu, Hirak S.; Marton, Laurence J.; Frydman, Benjamin


Book ID
121678737
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
192 KB
Volume
41
Category
Article
ISSN
0022-2623

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โœ Gaetano Marverti; Giorgio Piccinini; Stefania Ghiaroni; Daniela Barbieri; Daniel ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 133 KB ๐Ÿ‘ 1 views

The results presented here demonstrate that a cisdiamminedichloroplatinum(II) (DDP)-resistant human ovarian-carcinoma cell line is also cross-resistant to the spermine analogue N 1 ,N 12 -bis(ethyl)spermine (BESPM). We report that C13\* cells, which are approximately 20-fold resistant to DDP, simila