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Psoralen Analogues: Synthesis, Inhibitory Activity of Growth of Human Tumor Cell Lines and Computational Studies.

✍ Scribed by A. M. A. G. Oliveira; M. Manuela M. Raposo; A. M. F. Oliveira-Campos; A. E. H. Machado; Prapawadee Puapairoj; Madalena Pedro; Maria Sao Jose Nascimento; Cesar Portela; Carlos Afonso; Madalena Pinto


Publisher
John Wiley and Sons
Year
2006
Weight
17 KB
Volume
37
Category
Article
ISSN
0931-7597

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The GAS1 gene product induces growth arrest through a p53-dependent mechanism. To investigate whether GAS1 is a tumor suppressor gene, we transfected GAS1-negative human tumor cells with GAS1 plasmids and analyzed growth characteristics of stable transfectants. When a constitutively expressing GAS1