Nontransferrin-bound serum iron in thalassemia and sickle cell patients
β Scribed by Nahed K. Ahmed; Marwan Hanna; Winfred Wang
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 331 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0020-711X
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## Abstract ## Purpose To evaluate the magnetic properties of the spleen in chronically transfused, ironβoverloaded patients with sickle cell disease (SCD) and thalassemia major (TM) and to compare splenic iron burdens to those in the liver, heart, pancreas, and kidneys. ## Materials and Methods
## Abstract Patients with sickle cell disease (SCD) appear to be at lower risk of endocrinopathies and cardiac dysfunction than those with thalassemia major (TM). Circulating redox active iron is lower in these patients, possibly due to increased systemic inflammation and circulating cytokines. Hep
Cerebrovascular accidents (CVA) as a complication of sickle cell disease occur most frequently in childhood. Life-long transfusion prevents recurrent stroke, but inevitably leads to iron overload. Although effective chelation exists, many patients are not compliant. Erythrocytapheresis, an automated