Nontransferrin-bound iron in transfused patients with sickle cell disease
โ Scribed by A. INATI; K. M. MUSALLAM; M. D. CAPPELLINI; L. DUCA; A. T. TAHER
- Book ID
- 111415232
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 147 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1751-5521
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Cerebrovascular accidents (CVA) as a complication of sickle cell disease occur most frequently in childhood. Life-long transfusion prevents recurrent stroke, but inevitably leads to iron overload. Although effective chelation exists, many patients are not compliant. Erythrocytapheresis, an automated
The transfusion histories over a 33-month period of 50 patients with sickle cell disease were reviewed to determine the frequency of alloimmunization to red cell antigens following transfusion in these patients. There were 30 females and 20 males, aged 19--49 years. Eighteen (36%) were immunized of