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Nonnucleoside Human Cytomegalovirus Inhibitors: Synthesis and Antiviral Evaluation of (Chlorophenylmethyl)benzothiadiazine Dioxide Derivatives

✍ Scribed by Martinez, Ana; Gil, Carmen; Perez, Concepción; Castro, Ana; Prieto, Columbiana; Otero, Joaquín; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; De Clercq, Erik

Book ID: 120934361
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 146 KB
Volume: 43
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm000118q

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## Abstract A series of 2,1,3‐ and 1,2,4‐benzothiadiazine derivatives were synthesized by alkylation __via__ Mitsunobu reaction and evaluated for their antiviral activity against ADV, HHV‐6, Cox‐B5 and H‐CMV. Most of them were active at micromolar level against one or more viral strains. All the mo