✦ LIBER ✦

Synthesis and antiviral activity of new benzothiadiazine dioxide derivatives

✍ Scribed by Annalisa Tait; Amedeo Luppi; Claudio Cermelli

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 187 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410516

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✦ Synopsis

Abstract

A series of 2,1,3‐ and 1,2,4‐benzothiadiazine derivatives were synthesized by alkylation via Mitsunobu reaction and evaluated for their antiviral activity against ADV, HHV‐6, Cox‐B5 and H‐CMV. Most of them were active at micromolar level against one or more viral strains. All the molecules studied are poorly cytotoxic (maximum non toxic concentrations were >25μM), except one compound that presents a higher cytotoxicity (maximum non toxic concentration was 6 μM).

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