Synthesis and Antiviral Activities of Chiral Thiourea Derivatives

✍ Scribed by Zhikun YAN; Xuejian CAI; Xuan YANG; Baoan SONG; Zhuo CHEN; S. Pinaki BHADURY; Deyu HU; Linhong JIN; Wei XUE; Ping LU

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 127 KB
• Volume: 27
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200990097

✦ Synopsis

Abstract

An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF~6~. The ionic solvent can be recovered and reused without any loss of its activity. The target compounds were characterized by elemental analysis, IR, ^1^H NMR and ^13^C NMR spectral data. According to the preliminary bioassay, some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L. Title chiral compound 3i was found to possess good in vivo protection, inactivation and curative activities of 57.0%, 96.4% and 55.0%, respectively against TMV with an inhibitory concentration at 500 mg/L. The title chiral compound 3i revealed better inactivation effect on TMV (EC~50~=50.8 µg/mL) than Ningnanmycin (EC~50~=60.2 µg/mL).