A new antirheumatic, TAK-603, shows nonlinear pharmacokinetics in both animals and humans. To elucidate the mechanism of these nonlinear pharmacokinetics, in vivo and in vitro metabolism of 14 C-labeled TAK-603 ([ 14 C]TAK-603) was studied using rats as these resemble humans in their metabolic profi
Nonlinear pharmacokinetics of TAK-044, a new endothelin antagonist, in rats
β Scribed by Toshiyuki Takeuchi; Yoshihiko Tagawa; Kiyoshi Hagihara; Yoshihiro Maeshiba; Kenji Yamashita; Ryoichi Tsukuda; Yoshinobu Yoshimura
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 147 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.262
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