Incubation of (R)-tazofelone and (S)-tazofelone in rat, dog, and human liver microsomes demonstrated that the (R)-tazofelone enantiomer was more rapidly metabolized, with two diastereomeric sulfoxides as the major metabolites formed in all three species. The two diasteresomers epimerized at physiolo
Pharmacokinetics of E-6087, a new anti-inflammatory agent, in rats and dogs
✍ Scribed by Raquel F. Reinoso; Ramón Farrán; Trinidad Moragón; Antonio García-Soret; Lluis Martínez
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 139 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.258
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