## Abstract The dose‐dependent pharmacokinetic parameters of a new neuroprotective agent for ischemia‐reperfusion damage, KR‐31378, were evaluated after intravenous and oral administration, 10, 20, and 50 mg/kg, to rats. After intravenous administration of 50 mg/kg, the dose‐normalized (10 mg/kg) A
Pharmacokinetics of a novel antiangiogenic agent KR-31831 in rats
✍ Scribed by Sook J. Kim; Hong I. Lee; Hye Y. Ji; Ya Moon; In B. Paek; Sunkyung Lee; Kyu Y. Yi; Sun D. Yoo; Hye S. Lee
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 89 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.427
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
beta-Elemene, a natural sesquiterpene, is a novel anti-tumor agent. The pharmacokinetics of beta-elemene after single i.v. administration have been investigated in male SD rats. beta-Elemene was administered at three doses (50, 75 and 100 mg/kg) and a full pharmacokinetic profile was obtained. beta-
## Abstract The dose‐dependency of the pharmacokinetics of a new Na^+^/H^+^ exchanger inhibitor, KR‐33028 was evaluated in rats after intravenous and oral administration. After intravenous administration of KR‐33028 (1, 5, 10 and 20mg/kg doses), the systemic clearance (__Cl__) was reduced and __AUC
Ebastine (EBS), a novel nonsedative antiallergic agent, is similar to terfenadine in its chemical structure. However, clinical arrhythmogenicity of EBS remains controversial. In this study, we evaluated the possible arrhythmogenic potency of EBS as assessed by QT prolongation from a pharmacokinetic-