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Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood–brain barrier in mice and rats

✍ Scribed by Salvatore Cisternino; Fanchon Bourasset; Yves Archimbaud; Dorothée Sémiond; Gérard Sanderink; Jean-Michel Scherrmann


Book ID
110007700
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
210 KB
Volume
138
Category
Article
ISSN
0007-1188

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This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded