๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Region-Specific Overexpression of P-glycoprotein at the Blood-Brain Barrier Affects Brain Uptake of Phenytoin in Epileptic Rats

โœ Scribed by van Vliet, E. A.; van Schaik, R.; Edelbroek, P. M.; Voskuyl, R. A.; Redeker, S.; Aronica, E.; Wadman, W. J.; Gorter, J. A.

Book ID
125544254
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2007
Tongue
English
Weight
175 KB
Volume
322
Category
Article
ISSN
0022-3565

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Pharmacokinetics of P-glycoprotein inhib
Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier
โœ Stina Syvรคnen; Andrew Hooker; Obaidur Rahman; Helena Wilking; Gunnar Blomquist; ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 338 KB

This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded

Enhanced cerebral uptake of receptor lig
Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the bloodโ€“brain barrier
โœ P. Doze; A. Van Waarde; P.H. Elsinga; N.H. Hendrikse;; W. Vaalburg ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 170 KB ๐Ÿ‘ 2 views

Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and