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Noninvasive in vivo 13C-NMR spectroscopy of a 13C-labeled xenobiotic in the rat

✍ Scribed by D. Lanens; H.J. Muller; F. Van de Vyver; Tj. de Cock-Bunning; M. Spanoghe; A. Van der Linden; G.J. Mulder; R. Dommisse; J. Lugtenburg

Book ID
103909611
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
608 KB
Volume
10
Category
Article
ISSN
0730-725X

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✦ Synopsis

This study demonstrates that the xenobiotic product, 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloro-3-13C-propane can be monitored in the liver of an intact animal by in vivo 13C surface coil NMR spectroscopy after intraperitoneal administration. The carbon-13 label could be detected after a single dose of only 200 mg/kg of the product. The intrahepatic changes of the signal intensity of the labeled product were monitored as a function of time. No signals corresponding to metabolites could be detected.

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