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Multilabeled 13C substrates as probes in In vivo13C and 1H NMR spectroscopy

✍ Scribed by Basil Künnecke; Sebastian Cerdan

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
355 KB
Volume
2
Category
Article
ISSN
0952-3480

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✦ Synopsis

The potential use of I3C multilabeled substrates has been studied in biological applications using in uiuo and in uitro proton and I3C NMR spectroscopy. In OC NMR spectroscopy, multilabeled compounds allow the simultaneous observation of several nuclei or increase distinctly the signal to noise ratio due to a higher degree of enrichment. Contiguous labeling of substrates leads to homonuclear 13C-13C spin couplings and provides a simple means to distinguish between endogenous stores of metabolites and metabolites derived from added substrates.

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