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Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1

✍ Scribed by D.R. Buckle; B.C.C. Cantello; M.A. Cawthorne; P.J. Coyle; D.K. Dean; A. Faller; D. Haigh; R.M. Hindley; L.J. Jefcott; C.A. Lister; I.L. Pinto; H.K. Rami; D.G. Smith; S.A. Smith


Book ID
103983527
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
229 KB
Volume
6
Category
Article
ISSN
0960-894X

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Non thiazolidinedione antihyperglycaemic
✍ D.R. Buckle; B.C.C. Cantello; M.A. Cawthorne; P.J. Coyle; D.K. Dean; A. Faller; 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 324 KB

The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents' can be replaced by a range of o~-heteroatom functionalised ~-phenylpropanoic acids, o~-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the ~-ethoxyacid 15 (SB 213068), is one of the most po