Non thiazolidinedione antihyperglycaemic
Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids
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D.R. Buckle; B.C.C. Cantello; M.A. Cawthorne; P.J. Coyle; D.K. Dean; A. Faller;
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Article
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1996
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Elsevier Science
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English
⚖ 324 KB
The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents' can be replaced by a range of o~-heteroatom functionalised ~-phenylpropanoic acids, o~-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the ~-ethoxyacid 15 (SB 213068), is one of the most po