Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids

✍ Scribed by D.R. Buckle; B.C.C. Cantello; M.A. Cawthorne; P.J. Coyle; D.K. Dean; A. Faller; D. Haigh; R.M. Hindley; L.J. Jefcott; C.A. Lister; I.L. Pinto; H.K. Rami; D.G. Smith; S.A. Smith

• Book ID: 103983528
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 324 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(96)00383-6

✦ Synopsis

The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents' can be replaced by a range of o~-heteroatom functionalised ~-phenylpropanoic acids, o~-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the ~-ethoxyacid 15 (SB 213068), is one of the most potent antihyperglycaemic agents yet reported.