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ChemInform Abstract: Non Thiazolidinedione Antihyperglycaemic Agents. Part 1. α- Heteroatom Substituted β-Phenylpropanoic Acids.

✍ Scribed by D. R. BUCKLE; B. C. C. CANTELLO; M. A. CAWTHORNE; P. J. COYLE; D. K. DEAN; A. FALLER; D. HAIGH; R. M. HINDLEY; L. J. JEFCOTT; C. A. LISTER; I. L. PINTO; H. K. RAMI; D. G. SMITH; S. A. SMITH


Book ID
112042194
Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
27
Category
Article
ISSN
0931-7597

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Non thiazolidinedione antihyperglycaemic
✍ D.R. Buckle; B.C.C. Cantello; M.A. Cawthorne; P.J. Coyle; D.K. Dean; A. Faller; 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 324 KB

The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents' can be replaced by a range of o~-heteroatom functionalised ~-phenylpropanoic acids, o~-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the ~-ethoxyacid 15 (SB 213068), is one of the most po