Non-coding RNAs in Cardiovascular Diseas
β Junjie Xiao
π Library
π
2020
π Springer Singapore
π English
β¦ LIBER β¦
π
Non-coding RNAs in Complex Diseases: A Bioinformatics Perspective
β Scribed by Xia Li, Juan Xu, Yun Xiao, Shangwei Ning, Yunpeng Zhang
- Publisher
- Springer Singapore
- Year
- 2018
- Tongue
- English
- Leaves
- 131
- Series
- Advances in Experimental Medicine and Biology 1094
- Edition
- 1st ed.
- Category
- Library
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No coin nor oath required. For personal study only.
β¦ Synopsis
This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.
Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.
β¦ Table of Contents
Front Matter ....Pages i-x
Non-coding RNA Resources (Shangwei Ning, Xia Li)....Pages 1-7
Systematic Identification of Non-coding RNAs (Yun Xiao, Jing Hu, Wenkang Yin)....Pages 9-18
Functional Characterization of Non-coding RNAs Through Genomic Data Fusion (Yun Xiao, Min Yan, Chunyu Deng, Hongying Zhao)....Pages 19-28
Genomic-Scale Prioritization of Disease-Related Non-coding RNAs (Peng Wang, Xia Li)....Pages 29-37
Genome-Wide Mapping of SNPs in Non-coding RNAs (Shangwei Ning, Yunpeng Zhang)....Pages 39-48
Profiling DNA Methylation Patterns of Non-coding RNAs (ncRNAs) in Human Disease (Hui Zhi, Yongsheng Li, Li Wang)....Pages 49-64
Aberrant Epigenetic Modifications of Non-coding RNAs in Human Disease (Yun Xiao, Jinyuan Xu, Wenkang Yin)....Pages 65-75
Computationally Modeling ncRNA-ncRNA Crosstalk (Juan Xu, Jing Bai, Jun Xiao)....Pages 77-86
Computational Inferring of Risk Subpathways Mediated by Dysfunctional Non-coding RNAs (Yanjun Xu, Yunpeng Zhang, Xia Li)....Pages 87-95
Computational Identification of Cross-Talking ceRNAs (Yongsheng Li, Caiqin Huo, Xiaoyu Lin, Juan Xu)....Pages 97-108
Prediction of Non-coding RNAs as Drug Targets (Wei Jiang, Yingli Lv, Shuyuan Wang)....Pages 109-115
Methods for Identification of Protein-RNA Interaction (Juan Xu, Zishan Wang, Xiyun Jin, Lili Li, Tao Pan)....Pages 117-126
β¦ Subjects
Life Sciences; Bioinformatics; Human Genetics
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