Non-coding RNAs in Colorectal Cancer

✍ Scribed by Ondrej Slaby, George A. Calin (eds.)

Publisher: Springer International Publishing
Year: 2016
Tongue: English
Leaves: 251
Series: Advances in Experimental Medicine and Biology 937
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer.

This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response.

The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.

✦ Table of Contents

Front Matter....Pages i-viii
Front Matter....Pages 1-1
Non-coding RNAs: Classification, Biology and Functioning....Pages 3-17
Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancer....Pages 19-51
MicroRNAs and Inflammation in Colorectal Cancer....Pages 53-69
Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer....Pages 71-92
Non-coding RNAs Functioning in Colorectal Cancer Stem Cells....Pages 93-108
MicroRNA Methylation in Colorectal Cancer....Pages 109-122
Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer....Pages 123-149
Front Matter....Pages 151-151
Non-coding RNAs as Biomarkers for Colorectal Cancer Screening and Early Detection....Pages 153-170
Circulating Non-coding RNA as Biomarkers in Colorectal Cancer....Pages 171-181
Non-coding RNAs Enabling Prognostic Stratification and Prediction of Therapeutic Response in Colorectal Cancer Patients....Pages 183-204
Front Matter....Pages 205-205
Involvement of Non-coding RNAs in Chemo- and Radioresistance of Colorectal Cancer....Pages 207-228
Non-coding RNAs: Therapeutic Strategies and Delivery Systems....Pages 229-237
MicroRNAs as Therapeutic Targets and Colorectal Cancer Therapeutics....Pages 239-247
Back Matter....Pages 249-252

✦ Subjects

Cancer Research;Cell Biology;Human Genetics;Molecular Medicine;Life Sciences, general

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