Non-coding RNAs and Cancer

✍ Scribed by Muller Fabbri MD, Ph.D. (auth.), Muller Fabbri (eds.)

• Publisher: Springer-Verlag New York
• Year: 2014
• Tongue: English
• Leaves: 287
• Edition: 1
• Category: Library

✦ Synopsis

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.

✦ Table of Contents

Front Matter....Pages i-vi
Introduction....Pages 1-4
Biogenesis and Physiology of MicroRNAs....Pages 5-24
Detecting Noncoding RNA Expression: From Arrays to Next-Generation Sequencing....Pages 25-44
MicroRNAs in Solid Tumors....Pages 45-65
MicroRNAs in Hematologic Malignancies....Pages 67-95
miRNAs as Cancer Biomarkers....Pages 97-124
Unraveling the Complex Network of Interactions Between Noncoding RNAs and Epigenetics in Cancer....Pages 125-148
MicroRNA SNPs in Cancer....Pages 149-163
Bioinformatics Approaches to the Study of MicroRNAs....Pages 165-245
Beyond miRNAs: Role of Other Noncoding RNAs in Cancer....Pages 247-264
Translational Implications for Noncoding RNA in Cancer....Pages 265-282
Back Matter....Pages 283-284

✦ Subjects

Cancer Research; Cell Biology; Biochemistry, general; Posttranslational Modification; Gene Expression; Human Genetics