Long Non-coding RNAs in Human Disease

✍ Scribed by Kevin V. Morris (eds.)

• Publisher: Springer International Publishing
• Year: 2016
• Tongue: English
• Leaves: 267
• Series: Current Topics in Microbiology and Immunology 394
• Edition: 1
• Category: Library

✦ Synopsis

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

✦ Table of Contents

Front Matter....Pages i-viii
Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and Its Implications in Disease Conditions....Pages 1-27
Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease....Pages 29-39
Form and Function of Exosome-Associated Long Non-coding RNAs in Cancer....Pages 41-56
Long Noncoding RNAs in Lung Cancer....Pages 57-110
Pseudogene-Expressed RNAs: Emerging Roles in Gene Regulation and Disease....Pages 111-126
Functional Long Non-coding RNAs in Vascular Smooth Muscle Cells....Pages 127-141
Long Noncoding RNAs as Targets and Regulators of Nuclear Receptors....Pages 143-176
Noncoding Transcriptional Landscape in Human Aging....Pages 177-202
lncRNAs in Stress Response....Pages 203-236
Expression Specificity of Disease-Associated lncRNAs: Toward Personalized Medicine....Pages 237-258
Back Matter....Pages 259-262

✦ Subjects

Cancer Research; Immunology; Human Genetics