✦ LIBER ✦

Non-allelic heterogeneity of familial adenomatous polyposis

✍ Scribed by Tops, Carli M. J. ;Van Der Klift, Heleen M. ;Van Der Luijt, Rob B. ;Griffioen, Gerrit ;Taal, Babs G. ;Vasen, Hans F. A. ;Khan, P. Meera

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 528 KB
Volume: 47
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320470425

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Genetic evidence that Turcot syndrome is

Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis

✍ Tops, Carli M. J. ;Vasen, Hans F. A. ;Henegouwen, Gerard van Berge ;Simoons, Pet 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 651 KB

Turcot syndrome (TS) is a rare genetic disease in which brain tumors occur in association with colonic polyposis. Since Turcot's original description in 1959, there have been disagreements about the mode of inheritance as well as the clinical expression of this condition. Some investigators maintain

Risk of hepatoblastoma in familial adeno

Risk of hepatoblastoma in familial adenomatous polyposis

✍ Hughes, Linda J. ;Michels, Virginia V. 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB 👁 2 views

A mouse model of human familial adenomat

A mouse model of human familial adenomatous polyposis

✍ Yang, Kan; Edelmann, Winfried; Fan, Kunhua; Lau, Kirkland; Kolli, Venkateswara R 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views

In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were f

Risk of extracolonic cancer in familial

Risk of extracolonic cancer in familial adenomatous polyposis

✍ K. P. Nugent; A. D. Spigelman; Mr R. K. S. Phillips 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 2 views

Familial adenomatous polyposis (FAP) is characterized by the presence of more than 100 colorectal adenomatous polyps with an almost inevitable progression to cancer. At-risk individuals are screened and, if affected, prophylactic colectomy is performed. Operative options include total colectomy with

A remarkable APC mosaicism with two muta

A remarkable APC mosaicism with two mutant alleles in a family with familial adenomatous polyposis

✍ Stéphanie Baert-Desurmont; Nicolas Piton; Jacqueline Bou; Julie Tinat; Rosine Gu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

Characterization of two novel adenomatou

Characterization of two novel adenomatous polyposis coli (APC) gene mutations in patients with familial adenomatous polyposis (FAP)

✍ Bharati Bapat; Terri Berk; Angela Mitri; Zane Cohen; Steven Gallinger; Hartley S 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 398 KB 👁 2 views

Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua