Non-A, non-B hepatitis associated with the administration of intravenous immunoglobulin—transmission studies in chimpanzees
✍ Scribed by Sten Iwarson; Rune Wejstål; Eva Ruttimann; Janne Björkander; Belinda Seto; Philip Snoy; Robert J. Gerety
- Book ID
- 113383318
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 402 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0888-0786
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To further investigate the specificity of the monoclonal antibodies (48-1 and S-1) associated with non-A, non-B hepatitis, extensive immunofluoreecence studies were performed on liver biopsy specimens from chimpanzees with experimental hepatitis A, B, non-A, non-B or 6, or from normal chimpanzees. B
beta-propiolactone (beta-PL) treatment has been evaluated for its ability to inactivate 10(3.5) chimpanzee infectious doses (CID50) of the Hutchinson strain of hepatitis non-A, non-B virus (HNANBV). Two chimpanzees were inoculated with a beta-PL-treated immunoglobulin solution to which this dose of