✦ LIBER ✦

Inactivation of the Hutchinson strain of hepatitis non-A, non-B virus in intravenous immunoglobulin by β-propiolactone

✍ Scribed by Wolfgang Stephan; Herbert Dichtelmuller; Alfred M. Prince; Betsy Brotman; Tellervo Huima

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 454 KB
Volume: 26
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890260302

No coin nor oath required. For personal study only.

✦ Synopsis

beta-propiolactone (beta-PL) treatment has been evaluated for its ability to inactivate 10(3.5) chimpanzee infectious doses (CID50) of the Hutchinson strain of hepatitis non-A, non-B virus (HNANBV). Two chimpanzees were inoculated with a beta-PL-treated immunoglobulin solution to which this dose of the titrated virus had been added prior to beta-PL treatment. beta-PL treatment was performed in accordance with the production procedure used for a licensed intravenous immunoglobulin preparation. Neither animal developed hepatitis. When subsequently challenged with the same spiked immunoglobulin solution that had not been beta-PL treated, both animals developed clear-cut hepatitis non-A, non-B. The results of this experiment demonstrate that beta-PL treatment is effective for the inactivation of hepatitis non-A, non-B virus in intravenous immunoglobulin.

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