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No role for the CYP3A5*3 polymorphism in intestinal and hepatic metabolism of midazolam

✍ Scribed by D. Tomalik-Scharte; O. Doroshyenko; J. Kirchheiner; A. Jetter; A. Lazar; T. Klaassen; D. Frank; C. Wyen; G. Fätkenheuer; U. Fuhr

Book ID: 105921723
Publisher: Springer
Year: 2008
Tongue: English
Weight: 66 KB
Volume: 64
Category: Article
ISSN: 0031-6970
DOI: 10.1007/s00228-008-0503-9

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## Abstract This report characterizes the P450 isoenzymes involved in quinine metabolism in liver microsomes of the common brush‐tailed possum (__Trichosurus vulpecula__). The mean maximal velocity (__V__~max~) for 3‐hydroxyquinine formation in possum livers was 1,512 ± 510 pmol/mg protein/min (mal