Intestinal first-pass metabolism has a great impact on the bioavailability of CYP3A substrates in humans, and the in vivo impact has quantitatively been evaluated using CYP3A inhibitors or inducers. In vitro and in vivo preclinical investigations for intestinal metabolism are essential in clarifying
β¦ LIBER β¦
Poor Correlation Between Intestinal and Hepatic Metabolic Rates of CYP3A4 Substrates in Rats
β Scribed by Tetsuya Aiba; Yutaka Takehara; Marie Okuno; Yukiya Hashimoto
- Book ID
- 110437212
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 81 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0724-8741
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