𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Poor Correlation Between Intestinal and Hepatic Metabolic Rates of CYP3A4 Substrates in Rats

✍ Scribed by Tetsuya Aiba; Yutaka Takehara; Marie Okuno; Yukiya Hashimoto


Book ID
110437212
Publisher
Springer US
Year
2003
Tongue
English
Weight
81 KB
Volume
20
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Species differences in in vitro and in v
✍ Hiroshi Komura; Masahiro Iwaki πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 272 KB πŸ‘ 1 views

Intestinal first-pass metabolism has a great impact on the bioavailability of CYP3A substrates in humans, and the in vivo impact has quantitatively been evaluated using CYP3A inhibitors or inducers. In vitro and in vivo preclinical investigations for intestinal metabolism are essential in clarifying

Comparative study on altered hepatic met
✍ Jun-ichi Kusaba; Noriko Kajikawa; Hiromu Kawasaki; Yuji Kurosaki; Tetsuya Aiba πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 147 KB πŸ‘ 2 views

To examine the mechanism accounting for the diverse alteration of hepatic metabolism of CYP3A substrates observed with renal function being severely impaired, the hepatic drug metabolizing activity was evaluated using liver microsomes prepared from rats with glycerol-induced acute renal failure (ARF