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Halofantrine Metabolism in Microsomes in Man: Major Role of CYP 3A4 and CYP 3A5

โœ Scribed by B. BAUNE; J. P. FLINOIS; V. FURLAN; F. GIMENEZ; A. M. TABURET; L. BECQUEMONT; R. FARINOTTI


Book ID
111769783
Publisher
Pharmaceutical Press
Year
1999
Tongue
English
Weight
122 KB
Volume
51
Category
Article
ISSN
2042-7158

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In Vitro/in Vivo scaling of alprazolam m
โœ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB ๐Ÿ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a