๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes

โœ Scribed by Luigi Quintieri; Pietro Palatini; Alberto Nassi; Paolo Ruzza; Maura Floreani

Book ID
113488447
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
343 KB
Volume
75
Category
Article
ISSN
0006-2952

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Enzymes in addition to CYP3A4 and 3A5 me
Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes
โœ Yi Wang; Jashvant D. Unadkat ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 169 KB ๐Ÿ‘ 1 views

Both indinavir and troleandomycin (CYP3A inhibitors) are incapable of completely inhibiting dextromethorphan metabolism to 3-methoxymorphinan in human liver microsomes. It is hypothesized that CYPs in addition to CYP3A4 and 3A5 contribute to this biotransformation. The effect of CYP-selective inhibi

In Vitro/in Vivo scaling of alprazolam m
In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans
โœ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB ๐Ÿ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a