No genetic linkage or association between a functional promoter polymorphism in the monoamine oxidase-A gene and panic disorder
β Scribed by Hamilton, S P; Slager, S L; Heiman, G A; Haghighi, F; Klein, D F; Hodge, S E; Weissman, M M; Fyer, A J; Knowles, J A
- Book ID
- 110059232
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 92 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1359-4184
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~ W e have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder. Eighty-four unrelated Caucasian patients with DSM 111-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA a dinucleotide repeat in intron 2, a VN
## Abstract Monoamine oxidase A (MAOA) has been implicated in the control of aggression and/or impulsivity in humans and been involved in suicide. This gene has a functional polymorphism in which there is a variable number tandem repeat (VNTR) in the upstream region (MAOAβuVNTR). We hypothesized th