No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder
โ Scribed by Hamilton, S P; Slager, S L; Helleby, L; Heiman, G A; Klein, D F; Hodge, S E; Weissman, M M; Fyer, A J; Knowles, J A
- Book ID
- 110059246
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 128 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1359-4184
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Cholecystokinin tetrapeptide (CCKJ is known to induce panic attacks in patients with panic disorder at a lower dose than in normal controls. Therefore, the cholecystokinin B (CCKB) receptor gene is a candidate gene for panic disorder. We searched for mutations in the CCK, gene in 22 probands of pani
## Abstract The tetrapeptide of cholecystokinin (CCK), CCKโ4, is known to induce panic attacks in human subjects, while CCKโ8 is reported to have a therapeutic effect on schizophrenia symptoms. Recently, we have identified a novel microsatellite polymorphism in the 5โฒ upstream region of the CCK gen
Genetic variations in the 5-untranslated region and the coding region of the CCK-B receptor (CCK-BR) gene were investigated in healthy controls. Novel variants (-215 CโA, Leu37Phe, Arg319Glu) were found in addition to the mutations (Val125Iso, His207His, Arg215His, 2491 CโA) reported previously. In