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Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder

✍ Scribed by K. Yamada; E. Hattori; M. Shimizu; A. Sugaya; H. Shibuya; T. Yoshikawa


Book ID
106208347
Publisher
Springer
Year
2001
Tongue
English
Weight
164 KB
Volume
108
Category
Article
ISSN
1435-1463

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Cholecystokinin tetrapeptide (CCKJ is known to induce panic attacks in patients with panic disorder at a lower dose than in normal controls. Therefore, the cholecystokinin B (CCKB) receptor gene is a candidate gene for panic disorder. We searched for mutations in the CCK, gene in 22 probands of pani

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## Abstract The tetrapeptide of cholecystokinin (CCK), CCK‐4, is known to induce panic attacks in human subjects, while CCK‐8 is reported to have a therapeutic effect on schizophrenia symptoms. Recently, we have identified a novel microsatellite polymorphism in the 5β€² upstream region of the CCK gen