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No-carrier-added radiosynthesis of [123I]HIPDM: N,N,N′-trimethyl-N′-(2-hydroxy-3-methyl-5-[123I]iodobenzyl)-1,3-propanediamine

✍ Scribed by S.M. Moerlein; G.S. Lannoye; M.J. Welch

Book ID: 103922475
Publisher: Elsevier Science
Year: 1990
Weight: 444 KB
Volume: 41
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(90)90188-m

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✦ Synopsis

The multi-millicurie production of the SPECT radiopharmaceutical N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-[123I] iodobenzyl)-1,3-propanediamine [( 123I]HIPDM) in high specific activity is described. Using no-carrier-added electrophilic iododeprotonation reactions and HPLC purification, [123I]HIPDM can be isolated in 70-76% radiochemical yield and specific activity greater than 2000 Ci/mmol within an overal preparation time of 75 min. This methodology is readily adapted to the clinical setting, and eliminates the need for co-injection of macroscopic HIPDM in SPECT imaging procedures.

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