✦ LIBER ✦

Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

✍ Scribed by Meixiang Yu; Anu J. Airaksinen; Antony D. Gee; Simo Lötjönen; Jyrki T. Kuikka; Jouko J. Vepsäläinen; Jukka Hiltunen; Kim A. Bergström

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 93 KB
Volume: 45
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.619

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✦ Synopsis

Abstract

The radiosynthesis of a novel tropane derivative [^123^I]KUC‐25019, [[^123^I];N‐(3‐iodoprop‐(2__E__)‐enyl)‐2α‐(imino‐methyl)‐3β‐(3′,4′‐dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the ^123^I‐labeling synthesis. The no‐carrier‐added ^123^I‐labeling has about 20% yield, the specific activity of [^123^I]KUC‐25019 is > 107 GBq/µmol and the radiochemical purity of [^123^I] KUC‐25019 is >95%. Copyright © 2002 John Wiley & Sons, Ltd.

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