No association or linkage between the 5-HT2a/T102C polymorphism and schizophrenia in Irish families

✍ Scribed by Hawi, Ziarih; Myakishev, Maxim V.; Straub, Richard E.; O'Neill, Anthony; Kendler, Kenneth S.; Walsh, Dermot; Gill, Michael

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 16 KB
• Volume: 74
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19970725)74:4<370::aid-ajmg6>3.0.co;2-t

✦ Synopsis

Recent findings of an association between schizophrenia and a T102C polymorphism at the 5-HT 2a receptor gene (particularly with genotype 1-2 and 2-2 and allele 2) prompted us to investigate this marker in familial Irish schizophrenic patients, their relatives, and ethnically matched unrelated controls; 247 probands and 249 controls were included in this study. In contrast to some studies, we found no evidence of significant differences either in the frequency of the genotypes 1-2 and 2-2 or allele 2 between the schizophrenic patients and the controls. A transmission disequilibrium test, run on the full set of 265 families yielded no evidence to support linkage disequilibrium. Linkage analysis with both parametric and non-parametric methods yielded strongly negative results. Our findings are consistent with other recent association studies which argue against the involvement of the 5-HT 2a /T102C polymorphism in predisposition to schizophrenia. The positive findings reported to date might have occurred by chance or the apparent conflict may be due to genetic heterogeneity between samples. Am.